Chile is a safe country, with a low crime rate, but nevertheless, we recommend taking a taxi or Uber (not expensive) during nighttime. Keep money and valuables in a money belt or pouch under your clothes. Crimes that take place are usually crimes of opportunity, like pickpocket thieves, as opposed to violent crime, therefore be careful with your wallet and try not to use jewelry or expensive watches.
Some Chilean locations are worldwide known, like Torres del Paine, San Pedro de Atacama, and Easter Island, but in our opinion, you should try to get to know the following locations as well:
Not many people speak English in Chile. We recommend you learn basic words and have handy your mobile phone translator.
If you like traveling in remote areas and small villages, or if you are planning to visit Easter Island, then carry always Chilean pesos with you, just enough for any emergency (200 USD for example).
Although many foreigners do not have any problem drinking Chilean water, we recommend buying bottled water, especially in the north of Chile.
Always check the bills and change. Special care with taxi drivers and gas stations (I guess this is worldwide advice).
Cell phones: Cell phone coverage is very good in Chile. You will get a good signal in almost all cities and even in small towns. You may also find internet in Santiago's subway lines and also in most ski resorts, like Valle Nevado and Termas de Chillán.
If you bring US dollars or EUROS, take time and only bring bills in excellent conditions (not tear apart or too old) because otherwise they will not be accepted for change into local currency.
When you are driving and do not want to stop in a restaurant neither want to spend too much time "Pronto" Copec (the main gas station company in Chile) it is a great alternative for coffee, natural orange juice, and a clean bathroom.